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About TANGO2

    Home About TANGO2

    What is TANGO2 and TANGO2 Disease?

    TANGO2 itself is a protein coding gene on chromosome 22 (22q11.21). This gene belongs to the transport and Golgi organization family, whose members are predicted to play roles in secretory protein loading in the endoplasmic reticulum.

    TANGO2-related metabolic encephalopathy and arrhythmias is referred to as “metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration” (MECRCN) in OMIM. Identification of TANGO2 as a gene related to human disease is a relatively recent discovery – the initial two journal articles listed below were published in February 2016.

    Learn More About Signs & Symptoms

    Although there are some common symptoms and conditions across those affected by TANGO2 disease, there is also broad variability in terms of presentation and severity of them for each individual. In all cases though, the potential for rhabdomyolysis and life-threatening cardiac arrhythmia brought on by metabolic crisis is always there.

    TANGO2 Journal Articles

    • TANGO2: expanding the clinical phenotype and spectrum of pathogenic variants (Genetics in Medicine – Sep 2018)
    • TANGO2-Related Metabolic Encephalopathy and Arrhythmias (GeneReviews – Jan 2018)
    • Recurrent Muscle Weakness with Rhabdomyolysis, Metabolic Crises, and Cardiac Arrhythmia Due to Bi-allelic TANGO2 Mutations (American Journal of Human Genetics – Feb 2016)
    • Bi-allelic Truncating Mutations in TANGO2 Cause Infancy-Onset Recurrent Metabolic Crises with Encephalocardiomyopathy (American Journal of Human Genetics – Feb 2016)

    TANGO2 General References

    • NORD – TANGO2 Related Metabolic Encephalopathy and Arrhythmias (NORD – Sept 2018)
    • TANGO2 – Genetic and Rare Diseases Information Center (GARD) (GARD – March 2018)
    • TANGO2 Gene Card (Gene Cards)
    • TANGO2 Gene – Genetics Home Reference (NIH)
    • TANGO2 (Wikipedia)
    • Tango2 MGI Mouse Gene Detail (MGI)
    • www.tango2.it – Tango2 Disease Web Site
    • After the diagnosis brochures (CMTC-OVM)
    • It takes two to TANGO2 (Journal of Inherited Metabolic Disease (JIMD) podcasts)

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    Our Mission

    Our mission is to lead the way in finding a cure for TANGO2 related disease. We will do this by helping to fund, coordinate and guide scientific research that leads to a better understanding of how TANGO2 mutations affect people at the most basic cellular and biochemical pathway levels.

    Recent Posts

    • Teaming up with Solace Nutrition to help increase the quality of life for those with TANGO2 Disease

      December 1, 2020 | Uncategorized

    • Meet Agathe De Miniac, Author of ‘Tango2’

      November 11, 2020 | Uncategorized

    • RARE DISEASE CONNECTION TANGO2 PODCAST: Everything to know about TANGO2, from the experts

      October 7, 2020 | Uncategorized

    • FRIENDS & FAMILY RALLY FOR RYAN

      September 21, 2020 | Uncategorized

    • Chan Zuckerberg Initiative Grant Accelerates TANGO2 Research Foundation’s Funding and Hiring

      August 12, 2020 | Uncategorized

    Contact Us

    TANGO2 Research Foundation
    300 Plaza Middlesex
    Middletown, CT 06457

    info@tango2research.org

    Copyright 2018 - TANGO2 Research Foundation Incorporated | All Rights Reserved
    • About TANGO2
      • Symptoms
      • Early Signs of TANGO2
    • For Families
      • New Diagnosis
      • TANGO2 Study Now Underway
      • Our Stories
      • TANGO2 Conference – Houston 2019
      • Family Resources
      • Sammy’s Angels
      • Submit Your Story
    • Get Involved
      • Volunteer
      • Ways to Give
      • Fundraising Ideas
      • Apply For Grants (Researchers)
    • Research
    • About Us
      • Our Mission & History
      • Our Leadership
      • Scientific Advisory Board
      • Blog
      • Committees – CALL FOR VOLUNTEERS
      • Press Kit
    TANGO2 Research Foundation